Quittot N., Sebastiao M., Al-Halifa S., Bourgault S. (2018) Kinetic and Conformational Insights into Islet Amyloid Polypeptide Self-Assembly Using a Biarsenical Fluorogenic Probe. Bioconjugate Chemistry, doi: 10.1021/acs.bioconjchem.7b00827.

Tomas M.B., Shiao T.C., Nguyen P.T., Bourgault S., Roy R. (2018) Synthesis of analogs of trans-fagaramide and their cyototoxic activity. Pharmaceutical Chemistry Journal, 51: 995-1004.

Quittot N., Nguyen P.T., Nerée A.T., Lussier M.P., Bourgault S. (2017) Identification of a Conformational Heparin-Recognition Motif on the Peptide Hormone Secretin: Key Role for Cell Surface Binding. Biochemical Journal, 474:2249-2260.

Beaugrand M., Arnold A.A., Bourgault S., Williamson P.T., Marcotte I. (2017) Comparative study of the structure and interaction of the pore helices of the hERG and Kv1.5 potassium channels in model membranes. European Biophysical Journal, 46:549-559.

Quittot N., Sebastiao M., Bourgault S. (2017) Modulation of amyloid assembly by glycosaminoglycans: from mechanism to biological significance. Biochemistry and Cell Biology, 95:329-337.

Zottig X., Laporte-Wolwert M., Golizeh M., Ohlund L., Sleno L., Bourgault S. (2016) Effects of oxidative post-translational modifications on structural stability and self-assembly of λ6 immunoglobulin light chain. Biophysical Chemistry, 219:59-68.

Nguyen P.T., Sharma R., Reja R., De Carufel C.A., Roy R.*, Bourgault S. (2016) Low generation anionic dendrimers modulate islet amyloid polypeptide self-assembly and inhibit pancreatic β-cell toxicity. RSC Advances, 6:76360-76369.

Miloud  i K., Binet F., Wilson A., Cerani A., Oubaha M., Menard C., Henriques S., Mawambo G., Dejda A., Nguyen P.T., Rezende F.A., Bourgault S., Kennedy T.E., Sapieha P.* (2016) Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. The Journal of Clinical Investigation, 126:3006-3022.

Laporte-Wolwertz M., Quittot N., Nguyen P.T., Bourgault S. (2016) Role of l6 immunoglobulin light chain dimerization in amyloid formation. Biochimica Biophysica Acta, 1864:409-18

Tchoumi Neree A., Nguyen P.T., Bourgault S. (2015) Cell-penetrating Ability of Peptide Hormones: Key Role of Glycosaminoglycans Clustering. International Journal of Molecular Sciences, 16:27391-400.

De Carufel C.A., Quittot N., Nguyen P.T., Bourgault S. (2015) Delineating the Role of Helical Intermediates in Natively Unfolded Polypeptide Amyloid Assembly and Cytotoxicity. Angewandte Chemie International Edition, 54: 14833-7.

Nguyen P.T., Andraka N., De Carufel C.A., Bourgault S. (2015) Mechanistic contributions of biological cofactors in islet amyloid polypeptide amyloidogenesis. J. Diabetes Research, 2015:515307.

Chatenet D., Bourgault S., Forunier A. (2015) Design and application of light-activated probes for cellular signaling. Methods in Molecular Biology, 1234:17-30.

Tchoumi Neree A., Nguyen P.T., Chatenet D., Fournier, A., Bourgault S. (2014) Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP. FEBS Letters, 588:4590-6.

Other publications

De Carufel C.A., Nguyen P.T., Sahnouni S., Bourgault S. (2013) New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide (IAPP) amyloidogenesis and cytotoxicity. Biopolymers, 100:645-55.

Bourgault S., Solomon J.P., Reixach N., Kelly J.W. (2011) Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion. Biochemistry, 50: 1001-15.

Dejda A., Seaborn T., Bourgault S., Touzani O., Fournier A., Vaudry H., Vaudry D. (2011) PACAP38 and a novel stable analogue protect rat brain from ischemia: insight into mechanisms of action. Peptides, 32: 1207-16.

Solomon J.P., Bourgault S., Power E., Kelly J.W. (2011) Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension. Biochemistry, 50: 2486-98.

Bourgault S., Chatenet D., Wurtz O., Doan N.D., Leprince J., Vaudry H., Fournier A., Vaudry D. (2011) Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug. Curr. Pharm. Des., 10:1002-24.

Bourgault S., Choi S., Buxbaum J.N., Kelly J.W., Price J.L., Reixach N. (2011) Mechanisms of amyloidogenic transthyretin cytotoxicity inhibition by resveratrol analogs. Biochem. Biophys. Res. Commun., 410: 707-13.

Doan N.D., Bourgault S., Dejda A., Létourneau M., Detheux M., Vaudry D., Vaudry H., Chatenet D., Fournier A. (2011) Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects. Biochem. Pharmacol., 15: 552-61.

Dejda A., Bourgault S., Doan N.D., Létourneau M., Couvineau A., Vaudry H., Vaudry D., Fournier A. (2011) Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP. Biochimie, 93: 669-77.

Bourgault S., Vaudry D., Ségalas-Milazzo I., Guilhaudis L., Couvineau A., Laburthe M., Vaudry H., Fournier A. (2009) Molecular and Conformational Determinants of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) for Activation of the PAC1 Receptor. J. Med. Chem., 52: 3308-16.

Vaudry D., Falluel-Morel A., Bourgault S., Chow B.K., Basille M., Burel D., Wurtz O., Galas L., Fournier A., Hashimoto H., Vaudry H. (2009) Pituitary Adenylate Cyclase-Activating Polypeptide and its receptors: 20 years after the discovery. Pharmacol. Rev., 61: 283-357.

Bourgault S., Vaudry D., Dejda A., Doan N.D., Vaudry H., Fournier A. (2009) Pituitary Adenylate Cyclase-Activating Polypeptide: focus on structure-activity relationships of a neuroprotective peptide. Curr. Med. Chem., 16: 4462-80.

Bourgault S., Vaudry D., Raoult E., Guilhaudis L., Couvineau A., Laburthe M., Ségalas-Milazzo I., Vaudry H., Fournier A. (2008) Structural and biological analyses of truncated analogs of PACAP. J. Mol. Neuro., 36: 260-9.

Bourgault S., Vaudry D., Botia B., Couvineau A., Laburthe M., Vaudry H., Fournier A. (2008) Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides, 29: 919-32.

Doan N.D., Bourgault S., Létourneau M., Fournier A. (2008) Effectiveness of the Suzuki-Miyaura cross-coupling reaction for solid-phase peptide modification. J. Comb. Chem., 10: 44-51.

Dejda A., Jolivel V., Bourgault S., Seaborn T., Fournier A., Vaudry H., Vaudry D. (2008) Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: A better understanding toward a therapeutic potential in neurodegenerative diseases. J. Mol. Neuro., 36: 26-37.

Bourgault S., Létourneau M., Fournier A. (2007) Development of photolabile caged analogs of endothelin-1. Peptides, 28: 1074-82.

Ravni A., Bourgault S., Lebon A., Chan P., Galas L., Fournier A., Vaudry H., Gonzalez B.J., Eiden L.E. Vaudry D. (2006) The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. J. Neurochem., 98: 321-9.

Bourgault S., Létourneau M., Fournier A. (2005) Development and pharmacological characterization of caged urotensin II analogs. Peptides, 26: 1475-80.

Brkovic A., Hattenberger A., Kostensis E., Klabunde T., Flohr S., Kurz M., Bourgault S., Fournier A. (2003) Functional and binding characterizations of urotensin II related peptides in human and rat urotensin-II receptor assay. Journal of Pharmacology and Experimental Therapeutics, 306: 1200-9, 2003.